Item: After every round there is a 10% Chance to create a random potions of common quality.
Card: Use the Alchemist to combine 4 Potions of the same Quality to create on of the next higher Quality
Nice idea!
However it might come a bit too late :-) In the next release it is planned to remove the horadric cube from the game and make card trading (items, potions, towers) a central part of the game UI!